EnglishMegan Cavanagh as Judy Neutron/VOX
Mark DeCarlo as Hugh Neutron/Pilot/Arena Guard
Debi Derryberry as James 'Jimmy' Isaac Neutron
Jeffrey Garcia as Sheen Estevez
Bob Goen as Newscaster
Mary Hart as Newscaster
Carolyn Lawrence as Cindy Vortex
Andrea Martin as Mrs Fowl
Candi Milo as Nick Dean/Britanny/PJ
Rob Paulsen as Carl Wheezer/Carl's Mom and Dad/Kid in Classroom/K
Crystal Scales as Libby
Martin Short as Ooblar
Patrick Stewart as King Goobot
Jim Cummings as Ultra Lord/Mission Control/General
David L Lander as Yokian Guard/Gus
Kimberly Brooks as Zachery/Reporter/Angie
Paul Greenberg as Guard
Laraine Newman as Hostess
Jeannie Elias as Little Girl/Camera Person
Michael Hagiwara as Chris
John A Davis as Octapuke Kid/Guard/Bennie
Keith Alcorn as Bobby/Kid/Control Yokian
Richard Allen as Digital Voice
Brian Capshaw as Screamer
Cheryl Ray as Screamer
Mark Menza as Yokian Incubator Operator
Frank Welker as Goddard/Orthgot/Worm/Demon
Billy West as Poultra/Girl Eating Plant/Oyster/Yokian Officer/Ja
Matthew Russell as Hyperactive Kid/Arena Yokian
Carlos Alazraqui as Sheen's Dad
Dee Bradley Baker as NORAD Officer
Cathlen Gawlich as Cindy Vortex
Wanja Gerick as Sheen Estevez
Ilona Otto as James 'Jimmy' Isaac Neutron
Gerrit Schmidt-Foß as Carl Wheezer